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Rev. Sci. Instrum. 82, 115103 (2011); http://dx.doi.org/10.1063/1.3658825 (4 pages)

Noise reduction by signal combination in Fourier space applied to drift correction in optical tweezers

Alireza Mashaghi, Peter J. Vach, and Sander J. Tans

AMOLF institute, Science Park 104, 1098XG Amsterdam, The Netherlands

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(Received 19 August 2011; accepted 17 October 2011; published online 8 November 2011)

A general method is proposed to reduce noise by combining signals. Different measurements of the same physical quantity often exhibit different noise levels in different frequency ranges. Hence, a single high-fidelity signal can be constructed by combining the low-noise parts of the signals in Fourier space. We demonstrate this method by reducing noise in the measured bead-to-bead distance in an optical tweezers setup.

© 2011 American Institute of Physics

Article Outline

  1. COMBINING SIGNALS IN FOURIER SPACE
  2. OPTICAL TWEEZERS NOISE
  3. DNA STRETCHING EXPERIMENTS
  4. DISCUSSION

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0034-6748 (print)  
1089-7623 (online)

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    References

    S. F. Tolic-Norrelykke, E. Schaffer, J. Howard, F. S. Pavone, F. Julicher, and H. Flyvbjerg, Rev. Sci.c Instrum. 77, 103101 (2006)RSINAK000077000010103101000001.

    B. A. Mantooth, Z. J. Donhauser, K. F. Kelly, and P. S. Weiss, Rev. Sci. Instrum. 73, 313 (2002)RSINAK000073000002000313000001.


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