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Aug 2009

Volume 80, Issue 8, Articles (08xxxx)

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An open source/real-time atomic force microscope architecture to perform customizable force spectroscopy experiments

Donatello Materassi, Paolo Baschieri, Bruno Tiribilli, Giampaolo Zuccheri, and Bruno Samorì

Rev. Sci. Instrum. 80, 084301 (2009); http://dx.doi.org/10.1063/1.3194046 (6 pages) | Cited 5 times

Online Publication Date: 10 August 2009

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Show Abstract
We describe the realization of an atomic force microscope architecture designed to perform customizable experiments in a flexible and automatic way. Novel technological contributions are given by the software implementation platform (RTAI-LINUX), which is free and open source, and from a functional point of view, by the implementation of hard real-time control algorithms. Some other technical solutions such as a new way to estimate the optical lever constant are described as well. The adoption of this architecture provides many degrees of freedom in the device behavior and, furthermore, allows one to obtain a flexible experimental instrument at a relatively low cost. In particular, we show how such a system has been employed to obtain measures in sophisticated single-molecule force spectroscopy experiments [ Fernandez and Li, Science 303, 1674 (2004) ]. Experimental results on proteins already studied using the same methodologies are provided in order to show the reliability of the measure system.
Show PACS
07.79.Lh Atomic force microscopes
87.64.Dz Scanning tunneling and atomic force microscopy
87.14.E- Proteins
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