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Review of Scientific Instruments / Volume 73 / Issue 3 / TECHNIQUES

Rev. Sci. Instrum. 73, 1646 (2002); doi:10.1063/1.1445828 (3 pages)

Solving the crystallographic phase problem with reference-beam diffraction

Qun Shen, Daniel Pringle, Marian Szebenyi, and Jun Wang

Cornell High Energy Synchrotron Source (CHESS), Wilson Laboratory, Cornell University, Ithaca, New York 14853

By using a reference-beam diffraction data-collection technique, it is possible to directly measure a large number of relative phases of Bragg reflections on an area detector in a typical protein crystallography experiment. The technique, being developed at Cornell, incorporates the principle of three-beam diffraction into the most common method of data collection, i.e., the oscillating-crystal method, and allows recordings of many phase-sensitive three-beam interference profiles simultaneously. Recent advances include a dedicated five-circle κ diffractometer and new data acquisition and analysis algorithms. Experimental results on a protein crystal are presented and the strategies of using the measured phases for solving crystal structures are discussed. © 2002 American Institute of Physics.

© 2002 American Institute of Physics

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KEYWORDS and PACS

Keywords

X-ray diffraction, crystal structure, phase measurement, data acquisition, X-ray diffractometers, proteins

PACS

ARTICLE DATA

Permalink
http://link.aip.org/link/doi/10.1063/1.1445828

PUBLICATION DATA

ISSN:

0034-6748 (print)  
1089-7623 (online)

Publisher:

$abstract.society.value is a Member of CrossRef American Institute of Physics

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