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Top 20 Most Read Articles
October 2009
The 20 articles with the most full-text downloads during the month, in descending order.
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Rev. Sci. Instrum. 80, 081101 (2009); http://dx.doi.org/10.1063/1.3184828 (23 pages) Online Publication Date: 5 August 2009
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We review the current state of multiphoton microscopy. In particular, the requirements and limitations associated with high-speed multiphoton imaging are considered. A description of the different scanning technologies such as line scan, multifoci approaches, multidepth microscopy, and novel detection techniques is given. The main nonlinear optical contrast mechanisms employed in microscopy are reviewed, namely, multiphoton excitation fluorescence, second harmonic generation, and third harmonic generation. Techniques for optimizing these nonlinear mechanisms through a careful measurement of the spatial and temporal characteristics of the focal volume are discussed, and a brief summary of photobleaching effects is provided. Finally, we consider three new applications of multiphoton microscopy: nonlinear imaging in microfluidics as applied to chemical analysis and the use of two-photon absorption and self-phase modulation as contrast mechanisms applied to imaging problems in the medical sciences.
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Ultrasensitive low noise voltage amplifier for spectral analysis Rev. Sci. Instrum. 79, 084701 (2008); http://dx.doi.org/10.1063/1.2967339 (6 pages) Online Publication Date: 7 August 2008
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Recently we have proposed several voltage noise measurement methods that allow, at least in principle, the complete elimination of the noise introduced by the measurement amplifier. The most severe drawback of these methods is that they require a multistep measurement procedure. Since environmental conditions may change in the different measurement steps, the final result could be affected by these changes. This problem is solved by the one-step voltage noise measurement methodology based on a novel amplifier topology proposed in this paper. Circuit implementations for the amplifier building blocks based on operational amplifiers are critically discussed. The proposed approach is validated through measurements performed on a prototype circuit.
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WSXM: A software for scanning probe microscopy and a tool for nanotechnology Rev. Sci. Instrum. 78, 013705 (2007); http://dx.doi.org/10.1063/1.2432410 (8 pages) Online Publication Date: 31 January 2007
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In this work we briefly describe the most relevant features of WSXM, a freeware scanning probe microscopy software based on MS-Windows. The article is structured in three different sections: The introduction is a perspective on the importance of software on scanning probe microscopy. The second section is devoted to describe the general structure of the application; in this section the capabilities of WSXM to read third party files are stressed. Finally, a detailed discussion of some relevant procedures of the software is carried out.
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Confocal single molecule fluorescence spectroscopy in ultrahigh vacuum Rev. Sci. Instrum. 80, 103101 (2009); http://dx.doi.org/10.1063/1.3238505 (6 pages) Online Publication Date: 6 October 2009
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We have constructed an ultrahigh vacuum confocal fluorescence microscope with the purpose of performing single molecule spectroscopy under highly defined conditions. The microscope is designed for high stability while affording the capability of sample preparation, sample transfer, and optical detection in ultrahigh vacuum. It achieves near-diffraction-limited performance and allows the observation of single molecule fluorescence dynamics over extended periods of time. The design of the microscope is discussed in detail and the performance is demonstrated with single molecule fluorescence images and trajectories of N,N′-dibutylperylene-3,4,9,10-dicarboxyimide deposited onto several different surfaces. This instrument further enhances the array of available surface science techniques, permitting spectroscopic investigations of molecule-surface interactions at the single molecule level and on insulating surfaces.
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A compact apparatus for studies of element and phase-resolved ferromagnetic resonance Rev. Sci. Instrum. 80, 083903 (2009); http://dx.doi.org/10.1063/1.3190402 (7 pages) Online Publication Date: 11 August 2009
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We present a compact sample holder equipped with electromagnets and high frequency transmission lines; the sample holder is intended for combined x-ray magnetic circular dichroism (XMCD) and ferromagnetic resonance measurements (FMR). Time-resolved measurements of resonant x-ray detected FMR during forced precession are enabled by use of a rf excitation that is phase-locked to the storage ring bunch clock. Several applications of the combined XMCD+FMR technique are presented, demonstrating the flexibility of the experimental design.
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Thermal conductivity measurement from 30 to 750 K: the 3ω method Rev. Sci. Instrum. 61, 802 (1990); http://dx.doi.org/10.1063/1.1141498 (7 pages)
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An ac technique for measuring the thermal conductivity of dielectric solids between 30 and 750 K is described. This technique, the 3ω method, can be applied to bulk amorphous solids and crystals as well as amorphous films tens of microns thick. Errors from black‐body radiation are calculated to be less than 2% even at 1000 K. Data for a‐SiO2, Pyrex 7740, and Pyroceram 9606 are compared to results obtained by conventional techniques. |
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Spurious-free cantilever excitation in liquid by piezoactuator with flexure drive mechanism Rev. Sci. Instrum. 80, 103703 (2009); http://dx.doi.org/10.1063/1.3238484 (3 pages) Online Publication Date: 2 October 2009
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We have developed a cantilever holder for spurious-free cantilever excitation in liquid by piezoactuator. In the holder, generation and propagation of an acoustic wave are suppressed by “acoustic barriers,” i.e., boundaries between two materials having significantly different acoustic impedance while cantilever vibration is excited by “flexure drive mechanism” utilizing elastic deformation of a flexure hinge made of a material having a low elastic modulus. The holder enables to obtain amplitude and phase curves without spurious peaks in liquid using a piezoactuator, which ensures stability and accuracy of dynamic-mode atomic force microscopy in liquid.
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Rev. Sci. Instrum. 80, 103701 (2009); http://dx.doi.org/10.1063/1.3233896 (5 pages) Online Publication Date: 1 October 2009
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In this article, a switching gain proportional-integral-differential controller is used to reduce probe-loss affected regions in an image, obtained during tapping mode operation. Switching signal is derived from the “reliability index” signal, which demarcates regions where the tip has lost contact with the sample (probe-loss), within couple of cantilever oscillation cycles, thereby facilitating use of higher than optimal controller gain without deteriorating on-sample performance. Efficacy of the approach is demonstrated by imaging calibration sample at tip velocity close to 240 μm/s and plasmid DNA at tip velocity of 60 μm/s indicating significant reduction of probe-loss areas and recovery of lost sample features.
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Design and characterization of supersonic nozzles for wide focus laser-plasma interactions Rev. Sci. Instrum. 80, 103301 (2009); http://dx.doi.org/10.1063/1.3233895 (5 pages) Online Publication Date: 5 October 2009
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In this work we optimize the contour of supersonic nozzles to produce long and stable gas jets suitable to be used in loose focus laser-plasma applications. The nozzle design method takes into account the inclusion of a boundary layer that increases the length of the usable gas jet. Two 8 mm supersonic nozzles were characterized, one with a Mach number of 3 and another with a Mach number of 6, using a Mach–Zehnder interferometer performed with a He:Ne 4 cm expanded laser beam. The experimental results confirm that the inclusion of the boundary layer produces an 8 mm constant longitudinal density profile for the nozzle with a Mach number of 6 (NM6) and a 4.5 mm constant longitudinal density profile for the nozzle with a Mach number of 3 (NM3).
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Rev. Sci. Instrum. 76, 061101 (2005); http://dx.doi.org/10.1063/1.1927327 (12 pages) Online Publication Date: 26 May 2005
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Nanoelectromechanical systems (NEMS) are drawing interest from both technical and scientific communities. These are electromechanical systems, much like microelectromechanical systems, mostly operated in their resonant modes with dimensions in the deep submicron. In this size regime, they come with extremely high fundamental resonance frequencies, diminished active masses,and tolerable force constants; the quality (Q) factors of resonance are in the range Q ∼ 103–105—significantly higher than those of electrical resonant circuits. These attributes collectively make NEMS suitable for a multitude of technological applications such as ultrafast sensors, actuators, and signal processing components. Experimentally, NEMS are expected to open up investigations of phonon mediated mechanical processes and of the quantum behavior of mesoscopic mechanical systems. However, there still exist fundamental and technological challenges to NEMS optimization. In this review we shall provide a balanced introduction to NEMS by discussing the prospects and challenges in this rapidly developing field and outline an exciting emerging application, nanoelectromechanical mass detection.
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Femtosecond pulse shaping using spatial light modulators Rev. Sci. Instrum. 71, 1929 (2000); http://dx.doi.org/10.1063/1.1150614 (32 pages)
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We review the field of femtosecond pulse shaping, in which Fourier synthesis methods are used to generate nearly arbitrarily shaped ultrafast optical wave forms according to user specification. An emphasis is placed on programmable pulse shaping methods based on the use of spatial light modulators. After outlining the fundamental principles of pulse shaping, we then present a detailed discussion of pulse shaping using several different types of spatial light modulators. Finally, new research directions in pulse shaping, and applications of pulse shaping to optical communications, biomedical optical imaging, high power laser amplifiers, quantum control, and laser-electron beam interactions are reviewed. © 2000 American Institute of Physics. |
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Cantilever transducers as a platform for chemical and biological sensors Rev. Sci. Instrum. 75, 2229 (2004); http://dx.doi.org/10.1063/1.1763252 (25 pages) Online Publication Date: 21 June 2004
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Since the late 1980s there have been spectacular developments in micromechanical or microelectro-mechanical (MEMS) systems which have enabled the exploration of transduction modes that involve mechanical energy and are based primarily on mechanical phenomena. As a result an innovative family of chemical and biological sensors has emerged. In this article, we discuss sensors with transducers in a form of cantilevers. While MEMS represents a diverse family of designs, devices with simple cantilever configurations are especially attractive as transducers for chemical and biological sensors. The review deals with four important aspects of cantilever transducers: (i) operation principles and models; (ii) microfabrication; (iii) figures of merit; and (iv) applications of cantilever sensors. We also provide a brief analysis of historical predecessors of the modern cantilever sensors. © 2004 American Institute of Physics. |
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Rev. Sci. Instrum. 75, 2787 (2004); http://dx.doi.org/10.1063/1.1785844 (23 pages) Online Publication Date: 2 September 2004
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Since their invention just over 20 years ago, optical traps have emerged as a powerful tool with broad-reaching applications in biology and physics. Capabilities have evolved from simple manipulation to the application of calibrated forces on—and the measurement of nanometer-level displacements of—optically trapped objects. We review progress in the development of optical trapping apparatus, including instrument design considerations, position detection schemes and calibration techniques, with an emphasis on recent advances. We conclude with a brief summary of innovative optical trapping configurations and applications. |
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Large scan area high-speed atomic force microscopy using a resonant scanner Rev. Sci. Instrum. 80, 093707 (2009); http://dx.doi.org/10.1063/1.3227238 (5 pages) Online Publication Date: 22 September 2009
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A large scan area high-speed scan stage for atomic force microscopy using the resonant oscillation of a quartz bar has been constructed. The sample scanner can be used for high-speed imaging in both air and liquid environments. The well-defined time-position response of the scan stage due to the use of resonance allows highly linearized images to be obtained with a scan size up to 37.5 μm in 0.7 s. The scanner is demonstrated for imaging highly topographic silicon test samples and a semicrystalline polymer undergoing crystallization in air, while images of a polymer and a living bacteria, S. aureus, are obtained in liquid.
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Photoacoustic imaging in biomedicine Rev. Sci. Instrum. 77, 041101 (2006); http://dx.doi.org/10.1063/1.2195024 (22 pages) Online Publication Date: 17 April 2006
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Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) has the potential to image animal or human organs, such as the breast and the brain, with simultaneous high contrast and high spatial resolution. This article provides an overview of the rapidly expanding field of photoacoustic imaging for biomedical applications. Imaging techniques, including depth profiling in layered media, scanning tomography with focused ultrasonic transducers, image forming with an acoustic lens, and computed tomography with unfocused transducers, are introduced. Special emphasis is placed on computed tomography, including reconstruction algorithms, spatial resolution, and related recent experiments. Promising biomedical applications are discussed throughout the text, including (1) tomographic imaging of the skin and other superficial organs by laser-induced photoacoustic microscopy, which offers the critical advantages, over current high-resolution optical imaging modalities, of deeper imaging depth and higher absorption contrasts, (2) breast cancer detection by near-infrared light or radio-frequency–wave-induced photoacoustic imaging, which has important potential for early detection, and (3) small animal imaging by laser-induced photoacoustic imaging, which measures unique optical absorption contrasts related to important biochemical information and provides better resolution in deep tissues than optical imaging.
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Simultaneous axial and rotational electron beam velocity measurement using a phosphor scintillator Rev. Sci. Instrum. 72, 2268 (2001); http://dx.doi.org/10.1063/1.1366633 (3 pages)
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A novel method which measures beam axial and rotational velocity for any large-orbit beam with a common guiding center is described. Time-integrated beam velocity information is obtained using a beam block and phosphor scintillator. Results using this method are compared to capacitive probe measurements and trajectory modeling for the electron beam for a cyclotron autoresonance maser oscillator. © 2001 American Institute of Physics. |
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Rev. Sci. Instrum. 80, 104701 (2009); http://dx.doi.org/10.1063/1.3234261 (7 pages) Online Publication Date: 5 October 2009
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Due to their high stiffness, small dimensions, and low mass, piezoelectric stack actuators are capable of developing large displacements over bandwidths of greater than 100 kHz. However, due to their large electrical capacitance, the associated driving amplifier is usually limited in bandwidth to a few kilohertz or less. In this paper the limiting characteristics of piezoelectric drives are identified as the small-signal bandwidth, output impedance, cable inductance, and power dissipation. A new dual amplifier is introduced that exhibits a small-signal bandwidth of 2 MHz with a 100 nF capacitive load. The dual amplifier is comprised of a standard high-voltage amplifier combined with a fast low-voltage amplifier to improve performance at higher frequencies. Experiments demonstrate a 300 kHz sine wave of 20 Vp-p amplitude being applied to a 100 nF load with negligible phase delay and a peak-to-peak current of 3.8 A. With a voltage range of 200 V and peak current of 1.9 A a standard amplifier would require a worst-case power dissipation of 380 W. However, the dual-amplifier arrangement has a worst-case power dissipation of only 30 W. The penalty is reduced range at high frequencies and slower operation from the high-voltage stage.
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Rev. Sci. Instrum. 80, 093101 (2009); http://dx.doi.org/10.1063/1.3212667 (8 pages) Online Publication Date: 2 September 2009
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A complete system for the simultaneous monitoring of multiple cantilever sensors from different sensor arrays has been developed and tested for gas- and liquid-phase applications. The cantilever sensors are operated in static-deflection mode and the readout is achieved with phase-shifting interferometric microscopy (PSIM). In contrast to existing cantilever-sensor readout methods, PSIM is not dependent on alignment and allows the monitoring of the entire displacement profiles of all cantilevers within the field of view, using just one light source. To complement the PSIM readout, we have developed a sample cell, which can hold multiple cantilever-array chips, allows for very fast and reproducible sensor-chip replacement, has very low sample-volume requirements, and allows for individual or common addressing of all chips in the sample cell. We demonstrate the functionality of our microcantilever sensor system with a setup that can monitor eight cantilevers from four different sensor chips simultaneously.
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Time‐of‐Flight Mass Spectrometer with Improved Resolution Rev. Sci. Instrum. 26, 1150 (1955); http://dx.doi.org/10.1063/1.1715212 (8 pages) Online Publication Date: 29 December 2004
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A new type of ion gun is described which greatly improves the resolution of a nonmagnetic time‐of‐flight mass spectrometer. The focusing action of this gun is discussed and analyzed mathematically. The validity of the analysis and the practicability of the gun are demonstrated by the spectra obtained. The spectrometer is capable of measuring the relative abundance of adjacent masses well beyond 100 amu. |
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Thermoelectric properties and efficiency measurements under large temperature differences Rev. Sci. Instrum. 80, 093901 (2009); http://dx.doi.org/10.1063/1.3212668 (7 pages) Online Publication Date: 1 September 2009
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The maximum efficiency of a thermoelectric generator is determined by the material’s dimensionless figure of merit ZT. Real thermoelectric material properties are highly temperature dependent and are often measured individually using multiple measurement tools on different samples. As a result, reported ZT values have large uncertainties. In this work we present an experimental technique that eliminates some of these uncertainties. We measure the Seebeck coefficient, electrical conductivity, and thermal conductivity of a single element or leg, as well as the conversion efficiency, under a large temperature difference of 2–160 °C. The advantages of this technique include (1) the thermoelectric leg is mounted only once and all measurements are in the same direction and (2) the measured properties are corroborated by efficiency measurements. The directly measured power and efficiency are compared to the values calculated from the measured properties and agree within 0.4% and 2%, respectively. The realistic testing conditions of this technique make it ideal for material characterization prior to implementation in a real thermoelectric generator.
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